Fig. 3

Co-correlations reveal which taxa co-occur in high abundance and which can be considered disruptor taxa. A Co-correlation matrix of the top 20 most abundant genera and total microbial load. Only significant correlations (q < 0.1, Benjamini–Hochberg correction) are shown. Color of each marker is determined by the sign of the Spearman’s correlation coefficient and size of each marker is determined by the magnitude of the coefficient. Disruptor taxa labels are bolded. B Clustered co-correlation matrix of the top 16 genera ranked by the difference between their maximum abundance and mean abundance. Two common genera in the dataset are shown at the bottom for reference. The color of each square indicates the Spearman correlation coefficient from negative (blue) to positive (red). Disruptor taxa labels are bolded. Taxa with known relevance to human health are indicated. Enterobacteriaceae and Escherichia-Shigella are unique sequence variants from the Enterobacteriaceae family but only Escherichia-Shigella could be classified at the genus level. HAI=hospital acquired infection; IBS, irritable bowel syndrome; IBD, inflammatory bowel disease; HACEK, Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, Kingella