A meta-analysis study of the robustness and universality of gut microbiome-metabolome associations

Microbiome

Table 1 Studies included in the main analysis (additional details provided in Additional file 1: Table S1)

Dataset ID [abbreviation] ¹	Reference	# samples – control²	# samples – cases (disease/condition)²	Microbiome data description	Metabolome data description	# metabolites³
KIM_ADENOMAS [KI]	[27]	102	138 (Colorectal adenomas and CRC)	16S, V3-V5	Untargeted, MS	410
YACHIDA_CRC [YA]	[39]	127	220 (CRC)	WGSS	Targeted, MS	387
FRANZOSA_IBD [FR]	[22]	56	157 (IBD)	WGSS	Untargeted, MS	294
HE_INFANTS [HE]	[40]	68	–	16S, V4	Targeted, NMR	113
iHMP_IBD [iH]	[19]	72 [26]	212 [79] (IBD)	WGSS	Untargeted, MS	504
JACOBS_IBD_RELATIVES [JA]	[21]	54	–⁵	16S, V4	Untargeted, MS	45
MARS_IBS [MA]	[41]	70 [24]	143 [51] (IBS)	WGSS	Targeted, NMR, and MS	40
POYET_BIO_ML [PO]	[26]	141 [83]	–	16S⁴, V4	Untargeted, MS	313
SINHA_CRC [SI]	[42]	89	42 (CRC)	16S, V3-V4	Untargeted, MS	351
ERAWIJANTARI_GC [ER]	[43]	–⁵	42 (History of gastrectomy for GC)	WGSS	Untargeted, MS	342

¹The “Dataset ID” is formatted as follows: <First author/cohort name>_<Short cohort description>. The 2 letter abbreviations are used for plotting purposes
²Sample numbers refer only to samples included in the analysis herein. In cases of temporal datasets with multiple samples per individual, the number of individuals is noted in square brackets
³Number of HMDB-annotated metabolites. See “Methods” section
⁴WGSS data was also available but not used in the analysis herein
⁵This study group was not used
CRC colorectal cancer, MS mass spectrometry, 16S 16S rRNA gene sequencing, WGSS whole genome shotgun sequencing, IBD inflammatory bowel disease, IBS irritable bowel syndrome, GC gastric cancer

ISSN: 2049-2618