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Fig. 5 | Microbiome

Fig. 5

From: Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis

Fig. 5

Human UC intestinal contents are unable to maintain P-gp expression. A Diagram of human sample collection (BioRender). B Representative western blot of P-gp expression in human patient colon biopsies, showing healthy control versus UC patient, and uninvolved versus involved tissue, with samples from same UC patients indicated with brackets. C Densitometry data of B, N = 7–9 patients per group, red squares indicate 3 pan-colitis patients; **p = 0.0012, one-way ANOVA with Tukey’s multiple comparisons test. D Palmitoyl ethanolamide (PEA), oleoyl ethanolamide (OEA), and anandamide (AEA) 20:2 measured in mucosal brushings of human patients. N = 4 healthy controls, N = 7–8 UC patients. **p = 0.0013, one-way ANOVA with Tukey’s multiple comparisons test. E Functional P-gp expression induced by human patient fecal samples in T84 cells in vitro. Data are normalized to representative vehicle control bowel prep solution; N = 5–11 patients per group; *p < 0.05, one-way ANOVA with Tukey’s multiple comparisons

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