Fig. 1
From: Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease
Altered microbiota profiles in patients with CD from 2 different cohorts. a, b Species diversity in patients with CD and healthy volunteers were calculated using alpha diversity: Shannon (a) and Simpson indices (b). c Microbial clustering is shown based on Bray–Curtis dissimilarity principal coordinate analysis (PCoA) metrics for Cohort 1, Cohort 2, and HV. Ellipsoids represent a 95% confidence interval surrounding each group. There were 74 patients with CD in Cohort 1, 284 patients with CD in Cohort 2, and 43 healthy volunteers. Bars represent the median of all points. Nonparametric Mann–Whitney U test was used to identify the statistically significant differences between groups. (*P < 0.05, **P < 0.005, ***P < 0.0005, ****P < 0.0001)