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Fig. 7 | Microbiome

Fig. 7

From: Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Fig. 7

Prophylactic EGCG regulated the composition and function of intestinal microbiota. a α-diversity represented by the Sobs index on day 28. b PCoA plots on day 28 assessed by PERMANOVA among the four groups. The relative abundance of fecal bacterial phyla (c), and genera (d) presented in 99.5% of the community. Analysis of differences in the microbial taxa between the CON group and EGCG group (e), in DSS-treated mice with or without receiving EGCG (f) on day 27 was shown using LEfSe (LDA coupled with effect size measurements). Concentrations of fecal acetate (g), propionate (h), and butyrate (i) on day 27. Data are presented as means ± SEM (n = 8 per group). Statistical significance was determined using one-way ANOVA, followed by Tukey test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Spearman correlation between intestinal microbiota and anti-inflammatory or anti-oxidative parameters in healthy mice (j), and in DSS-treated mice (k) in response to prophylactic EGCG. The red color denotes a positive correlation, while blue color denotes a negative correlation. The intensity of the color is proportional to the strength of Spearman correlation. *P ≤ 0.05, ***P ≤ 0.001

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