Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis

Table 2 Relative abundance of microbiota at different taxon levels

Taxonomic level	Relative abundance			P value
Taxonomic level	Control	Rotenone	FMT	Overall	Con vs. Rot	Rot vs. FMT	Con vs. FMT
Phylum
Bacteroidetes	0.6148	0.4189	0.5962	0.0455	0.0104*	0.1049	0.8785
Candidatus Saccharibacteria	0.0032	0.0014	0.0125	0.0191	0.1304	0.0104*	0.0927
Proteobacteria	0.0266	0.0079	0.0314	0.0105	0.0180*	0.0074**	0.7984
Verrucomicrobia	0.0343	0.3284	0.0008	0.0001	0.0002***	0.0009***	0.0404*
Family
Coriobacteriaceae	0.0025	0.0024	0.0010	0.0109	1.0000	0.0047**	0.0574
Desulfovibrionaceae	0.0004	0.0014	0.0015	0.0142	0.0236*	0.6358	0.0653
Enterobacteriaceae	0.0034	0.0001	0.0005	0.0485	0.0574	0.0349*	0.3717
Helicobacteraceae	0.0054	0.0005	0.0223	0.0008	0.0180*	0.0002***	0.1949
Lactobacillaceae	0.0073	0.0096	0.0583	0.0054	0.5054	0.0070**	0.0574
Rikenellaceae	0.0087	0.0038	0.0046	0.0124	0.0070**	0.4005	0.4005
Verrucomicrobiaceae	0.0343	0.3284	0.0008	0.0001	0.0002***	0.0009***	0.0404*
Genus
Akkermansia	0.0343	0.3284	0.0008	0.0001	0.0002***	0.0009***	0.0404*
Alistipes	0.0087	0.0037	0.0045	0.0095	0.0086**	0.4005	0.1304
Barnesiella	0.0182	0.0070	0.0372	0.0427	0.1949	0.0207*	0.1605
Butyricicoccus	0.0014	0.0004	0.0027	0.0108	0.0653	0.0053**	0.2069
Desulfovibrio	0.0001	0.0010	0.0003	0.0066	0.0018**	0.0500*	0.5369
Helicobacter	0.0054	0.0005	0.0223	0.0008	0.0180*	0.0002***	0.1949
Lactobacillus	0.0073	0.0096	0.0583	0.0054	0.5054	0.0070**	0.0574
Saccharibacteria genera incertae sedis	0.0032	0.0014	0.0125	0.0191	0.1304	0.0104*	0.0927

*P < 0.05, **P < 0.01, ***P < 0.001. Statistical analysis by the Kruskal-Wallis multiple comparison test with the post-hoc Mann-Whitney U test

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