Skip to main content

Table 2 Pathways and enzymes differentially abundant in T1D women

From: Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

Function (Change ref. T1D) Function IDs Principal bacterial contributors a (bacterial clusters are in bold)
LPS production (↑) PWY-1269
K00748
K00912
K00979
K01447
K01627
K01791
K02517
K02536
K02852
K03270
K03771
K05807
K06041
K06142
K07091
K11720
K11934
DARAB5PISOM-RXN
UDPGLCNACEPIM-RXN
Escherichia coli, Akkermansia muciniphila, Bacteroides caccae, Alistipes finegoldii, Bacteroides dorei, Odoribacter splanchnicus, Alistipes shahii, Bacteroides fragilis, Bacteroides vulgatus, Bacteroides faecis, Bacteroides finegoldii, Bacteroides ovatus, Bacteroides sp. 2 1 22, Bacteroides sp. 4 3 47FAA, Bacteroides thetaiotaomicron, Bacteroides xylanisolvens, Alistipes onderdonkii, Bacteroides stercoris, Bacteroides uniformis, Comamonas testosteroni, Enterobacter cloacae, Escherichia sp. TW09276, Achromobacter xylosoxidans, Aggregatibacter aphrophilus, Azospira oryzae, Bacteroides cellulosilyticus, Bacteroides sp. 1 1 6, Bacteroides sp. 3 2 5, Campylobacter concisus, Campylobacter curvus, Campylobacter hominis, Chryseobacterium taeanense, Citrobacter freundii, Citrobacter koseri, Cronobacter sakazakii, Delftia acidovorans, Desulfovibrio desulfuricans, Escherichia fergusonii, Eubacterium siraeum, Haemophilus influenzae, Neisseria flavescens, Neisseria meningitidis, Neisseria subflava, Parabacteroides goldsteinii, Parabacteroides merdae, Porphyromonas asaccharolytica, Prevotella denticola, Prevotella melaninogenica, Pseudomonas nitroreducens, Pseudomonas putida, Salmonella enterica, Serratia liquefaciens, Shigella flexneri, Shigella sonnei
Vitamin K2 synthesis (↑) PWY-5838
PWY-5845
PWY-5850
PWY-5860
PWY-5861
PWY-5862
PWY-5896
K00330
K00334
K00338
K00340
K00343
K02523
K02548
Escherichia coli, Akkermansia muciniphila, Bacteroides sp. 4 3 47FAA, Bacteroides dorei, Bacteroides fragilis, Alistipes finegoldii, Bacteroides vulgatus, Bacteroides salyersiae, Bacteroides sp. 1 1 6, Bacteroides thetaiotaomicron, Odoribacter splanchnicus, Alistipes onderdonkii, Alistipes shahii, Bacteroides caccae, Bacteroides ovatus, Bifidobacterium longum, Enterobacter cloacae, Klebsiella pneumoniae, Porphyromonas asaccharolytica
Vitamin B6 synthesis (↓) K06215 Eubacterium rectale, Desulfovibrio piger
Vitamin B12 synthesis (↓) COBALSYN-PWY
K02189
K03394
K05934
K05936
K06042
RIBAZOLEPHOSPHAT-RXN
RXN-8770
2.7.1.156-RXN
COBINAMIDEKIN-RXN
COBINPGUANYLYLTRANS-RXN
RXN-14063
Eubacterium rectale, Faecalibacterium prausnitzii, Roseburia intestinalis, Desulfovibrio piger, Ruminococcus torques, Ruminococcus obeum, Citrobacter freundii, Citrobacter koseri, Collinsella aerofaciens, Coprococcus catus, Fusobacterium nucleatum, Fusobacterium periodonticum, Klebsiella sp. MS 92 3, Lactobacillus reuteri, Megamonas funiformis, Megamonas hypermegale, Megamonas rupellensis, Methanosphaera stadtmanae, Morganella morganii, Roseburia hominis, Salmonella enterica, Streptococcus australis, Streptococcus parasanguinis, Streptococcus sanguinis, Veillonella dispar, Veillonella parvula, Veillonella sp. oral taxon 158
SCFA production (↓) GLUCUROCAT-PWY
P42-PWY
PWY-5177
PWY-6507
PWY-7242
K00016
K00074
K00248
K00626
K01571
K01625
K01715
K03856
K04070
K03785
K15634
METHYLACETOACETYLCOATHI
OL-RXN
RXN-12561
RXN0-2044
RXN-11245
RXN-16133
RXN-12705
RXN-14275
RXN-12750
RXN-12490
RXN-11662
RXN-12570
ACETYL-COA-ACETYLTRANSFER-RXN
OHACYL-COA-DEHYDROG-RXN
Faecalibacterium prausnitzii, Ruminococcus torques, Eubacterium rectale, Roseburia intestinalis, Anaerostipes hadrus, Lachnospiraceae bacterium 5 1 63FAA, Roseburia inulinivorans, Roseburia hominis, Ruminococcus champanellensis, Bacteroides sp. 3 1 19, Bifidobacterium adolescentis, Bifidobacterium animalis, Eggerthella lenta, Eubacterium eligens, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum, Treponema succinifaciens
Mucin degradation (↓) K01207 Eubacterium rectale, Bifidobacterium adolescentis, Eubacterium siraeum, Ruminococcus bromii, Adlercreutzia equolifaciens, Roseburia intestinalis, Bifidobacterium bifidum, Streptococcus parasanguinis, Megamonas hypermegale
  1. a On average more abundant in the group with increased abundance of a given function