Table 2 Pathways and enzymes differentially abundant in T1D women
Function (Change ref. T1D) | Function IDs | Principal bacterial contributors a (bacterial clusters are in bold) |
|---|---|---|
LPS production (↑) | PWY-1269 K00748 K00912 K00979 K01447 K01627 K01791 K02517 K02536 K02852 K03270 K03771 K05807 K06041 K06142 K07091 K11720 K11934 DARAB5PISOM-RXN UDPGLCNACEPIM-RXN | Escherichia coli, Akkermansia muciniphila, Bacteroides caccae, Alistipes finegoldii, Bacteroides dorei, Odoribacter splanchnicus, Alistipes shahii, Bacteroides fragilis, Bacteroides vulgatus, Bacteroides faecis, Bacteroides finegoldii, Bacteroides ovatus, Bacteroides sp. 2 1 22, Bacteroides sp. 4 3 47FAA, Bacteroides thetaiotaomicron, Bacteroides xylanisolvens, Alistipes onderdonkii, Bacteroides stercoris, Bacteroides uniformis, Comamonas testosteroni, Enterobacter cloacae, Escherichia sp. TW09276, Achromobacter xylosoxidans, Aggregatibacter aphrophilus, Azospira oryzae, Bacteroides cellulosilyticus, Bacteroides sp. 1 1 6, Bacteroides sp. 3 2 5, Campylobacter concisus, Campylobacter curvus, Campylobacter hominis, Chryseobacterium taeanense, Citrobacter freundii, Citrobacter koseri, Cronobacter sakazakii, Delftia acidovorans, Desulfovibrio desulfuricans, Escherichia fergusonii, Eubacterium siraeum, Haemophilus influenzae, Neisseria flavescens, Neisseria meningitidis, Neisseria subflava, Parabacteroides goldsteinii, Parabacteroides merdae, Porphyromonas asaccharolytica, Prevotella denticola, Prevotella melaninogenica, Pseudomonas nitroreducens, Pseudomonas putida, Salmonella enterica, Serratia liquefaciens, Shigella flexneri, Shigella sonnei |
Vitamin K2 synthesis (↑) | PWY-5838 PWY-5845 PWY-5850 PWY-5860 PWY-5861 PWY-5862 PWY-5896 K00330 K00334 K00338 K00340 K00343 K02523 K02548 | Escherichia coli, Akkermansia muciniphila, Bacteroides sp. 4 3 47FAA, Bacteroides dorei, Bacteroides fragilis, Alistipes finegoldii, Bacteroides vulgatus, Bacteroides salyersiae, Bacteroides sp. 1 1 6, Bacteroides thetaiotaomicron, Odoribacter splanchnicus, Alistipes onderdonkii, Alistipes shahii, Bacteroides caccae, Bacteroides ovatus, Bifidobacterium longum, Enterobacter cloacae, Klebsiella pneumoniae, Porphyromonas asaccharolytica |
Vitamin B6 synthesis (↓) | K06215 | Eubacterium rectale, Desulfovibrio piger |
Vitamin B12 synthesis (↓) | COBALSYN-PWY K02189 K03394 K05934 K05936 K06042 RIBAZOLEPHOSPHAT-RXN RXN-8770 2.7.1.156-RXN COBINAMIDEKIN-RXN COBINPGUANYLYLTRANS-RXN RXN-14063 | Eubacterium rectale, Faecalibacterium prausnitzii, Roseburia intestinalis, Desulfovibrio piger, Ruminococcus torques, Ruminococcus obeum, Citrobacter freundii, Citrobacter koseri, Collinsella aerofaciens, Coprococcus catus, Fusobacterium nucleatum, Fusobacterium periodonticum, Klebsiella sp. MS 92 3, Lactobacillus reuteri, Megamonas funiformis, Megamonas hypermegale, Megamonas rupellensis, Methanosphaera stadtmanae, Morganella morganii, Roseburia hominis, Salmonella enterica, Streptococcus australis, Streptococcus parasanguinis, Streptococcus sanguinis, Veillonella dispar, Veillonella parvula, Veillonella sp. oral taxon 158 |
SCFA production (↓) | GLUCUROCAT-PWY P42-PWY PWY-5177 PWY-6507 PWY-7242 K00016 K00074 K00248 K00626 K01571 K01625 K01715 K03856 K04070 K03785 K15634 METHYLACETOACETYLCOATHI OL-RXN RXN-12561 RXN0-2044 RXN-11245 RXN-16133 RXN-12705 RXN-14275 RXN-12750 RXN-12490 RXN-11662 RXN-12570 ACETYL-COA-ACETYLTRANSFER-RXN OHACYL-COA-DEHYDROG-RXN | Faecalibacterium prausnitzii, Ruminococcus torques, Eubacterium rectale, Roseburia intestinalis, Anaerostipes hadrus, Lachnospiraceae bacterium 5 1 63FAA, Roseburia inulinivorans, Roseburia hominis, Ruminococcus champanellensis, Bacteroides sp. 3 1 19, Bifidobacterium adolescentis, Bifidobacterium animalis, Eggerthella lenta, Eubacterium eligens, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum, Treponema succinifaciens |
Mucin degradation (↓) | K01207 | Eubacterium rectale, Bifidobacterium adolescentis, Eubacterium siraeum, Ruminococcus bromii, Adlercreutzia equolifaciens, Roseburia intestinalis, Bifidobacterium bifidum, Streptococcus parasanguinis, Megamonas hypermegale |