Fig. 5

Means and standard errors of the log2-transformed fitted values shown as a point in each trimester for differentially abundant functional features in women with (red) and without (blue) T1D. One example for each of six broad categories is shown: lipopolysaccharide (LPS) production (CMP–3–deoxy–d–manno–octulosonate synthesis [PWY–1269]), vitamin K2 synthesis (superpathway of menaquinol–8 synthesis [PWY–5838]), vitamin B6 synthesis (pyridoxal 5′–phosphate synthase [K06215]), vitamin B12 synthesis (adenosylcobalamin salvage from cobinamide [COBALSYN–PWY]), short-chain fatty acid (SCFA) production (3–hydroxybutyryl–CoA dehydrogenase [K00074]) and mucin degradation (beta–N–acetylhexosaminidase [K01207]). * in the top right corner denotes a significant difference (FDR < 0.1) between groups throughout pregnancy; * between points denotes a significant difference (FDR < 0.1) between groups in that trimester