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Table 1 Predicted proteins homologous to enzymes involved in metabolic pathways from tyrosine to p-Cresol in species related to bacterial taxa identified as upregulated both upon p-Cresol treatment and upon FMTp-Cresol

From: The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Species Direct pathway Indirect pathway
ThiH HpdA
Accession % Identity E-score Accession % Identity E-score
Anaerobium acetethylicum WP_091230597.1 38.90 3.00E− 72 WP_091236185.1 37.62 4E− 66
Duncaniella dubosii WP_123615573.1 46.85 3.00E− 121 WP_123485485.1 32.59 5E− 13
Barnesiella sp. MBD5257534.1 48.49 1.00E− 129 - - -
Barnesiella sp. An55 WP_087424377.1 49.04 3.00E− 125 - - -
Barnesiella intestinihominis WP_195342987.1 48.65 2.00E− 124 - - -
Barnesiella viscericola WP_025277286.1 47.95 6.00E− 123 - - -
  1. Reference enzyme protein sequences from ThiH (NP_418417.1, 2-iminoacetate synthase from Escherichia coli K12, metabolizing tyrosine to p-Cresol) and HpdA (sp|Q84F14|HPDA_CLODI, 4-hydroxyphenylacetate decarboxylase activating enzyme from Clostridioides difficile, metabolizing 4-hydroxyphenylacteate to p-Cresol) were used to conduct a Blast search against sequences from the Anaerobium genus and from the Muribaculaceae family. Only sequences covering more than 50% of the query sequence and presenting amino acid identity above 30% were considered potential homologous enzymes. See also Tab. S3 (Additional file 4) for the full blast analysis