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Fig. 2 | Microbiome

Fig. 2

From: Microbiota long-term dynamics and prediction of acute graft-versus-host disease in pediatric allogeneic stem cell transplantation

Fig. 2

Temporal microbial community dynamics in the gut. A Relative abundances over time of the 12 most abundant families in the gut. B Tree-based sparse linear discriminant analysis (LDA). Coefficients of discriminating clades of ASVs on the first LDA axis, colored by taxonomic family, and plotted along the phylogenetic tree. C Trajectories of ASVs affiliated with the families Enterococcaceae and Lactobacillaceae, with increasing abundances after HSCT. The most abundant discriminating ASV for each family is indicated. D Trajectories of ASVs affiliated with the families Lachnospiraceae and Ruminococcaceae, with decreasing abundances after HSCT and recovery at late follow-up time points. The most abundant discriminating ASV for Blautia spp. is indicated. Detailed taxonomic information and LDA-coefficients of the displayed ASVs are listed in Additional File 1: Table S2. E PCA biplots with the top 100 predictors (ASVs) identified by PCA (left) and the top predictors (ASVs) identified by sparse LDA (right). The time points are indicated in the same color as in Fig. 1C (phase I: yellow colors; phase II: red colors; phase III: blue colors). The PCA plots with dimensions 3 and 4 are displayed here as the separation by time point was best resolved in these dimensions. The PCA plots resolved at the first two dimensions are available from https://doi.org/10.6084/m9.figshare.14510661

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