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Fig. 1 | Microbiome

Fig. 1

From: Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

Fig. 1

Different phenotype features between ob/ob and db/db mice. (a) ∆ (Delta) of the body weight (starting at day 0) and final body weight (g). (b) ∆ of the fat mass (starting at day 3) and final fat mass (g) measured by time-domain nuclear magnetic resonance (TD-NMR). (c) ∆ of the lean mass (starting at day 3) and final lean mass (g) measured by time-domain nuclear magnetic resonance (TD-NMR). (d) Adipose tissues (SAT: subcutaneous; EAT: epididymal; VAT: visceral; BAT: brown) weight (g). (e) Muscles (SOL: soleus; GAS: gastrocnemius; TA: tibialis; VL: vastus lateralis) weight (g). (f) Size of the adipocytes in the subcutaneous adipose tissue (SAT). Scale bar, 100 μm; magnification, × 20. (g) Morphology of the liver, SAT, and cecum. (h) Plasma glucose (mg/dL) profile after 1 g/kg glucose oral challenge in freely moving mice and (i) the mean area under the curve (AUC) measured between 0 and 120 min after glucose loading. (j) Plasma insulin (μg/L) measured 30 min before and 15 min after glucose loading. (k) Insulin resistance index determined by multiplying the AUC of blood glucose by the AUC of insulin. Green: CT ob lean mice, red: ob/ob mice, blue CT db lean mice, and violet: db/db mice. Data are presented as the mean ± s.e.m, **P < 0.01, ****P < 0.0001 (n = 8–10). Data were analyzed using two-way ANOVA followed by Tukey’s post hoc test for (a–c) and (h) and according to one-way ANOVA followed by Tukey’s post hoc test for (df) and (ik)

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