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Fig. 1 | Microbiome

Fig. 1

From: Genetic and behavioral adaptation of Candida parapsilosis to the microbiome of hospitalized infants revealed by in situ genomics, transcriptomics, and proteomics

Fig. 1

Analysis of C. parapsilosis genomic variability reveals a potential hospital associated population and the presence of SNV hotspots. A A phylogenetic tree of C. parapsilosis strains constructed from concatenated SNVs. Metagenome-derived hospital strains from this study demarcated as the purple clade. ANI comparisons and a C. albicans SNV tree are also available in Figures S1–S2. B Whole genome SNV density plots for each C. parapsilosis strain. Strain names in red are strains assembled from samples from infants or the NICU from Magee-Women’s Hospital. SNV density plotted in 1.3 kb sliding windows. Window size was selected based on ease of visualization. Chromosomes are separated with dashed lines. Total bar height represents total SNV density, and homozygous SNV proportion is labeled in red whereas heterozygous is black. C Depiction of SNV hotspot overlaps between each strain. Pairwise overlap was calculated between each strain and plotted. Strain names in red are strains assembled from samples from infants or the NICU from Magee-Women’s Hospital. D Two example SNV hotspots. Individual SNVs are represented with red bars

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Microbiome

ISSN: 2049-2618

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