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Fig. 8 | Microbiome

Fig. 8

From: Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens

Fig. 8

Schematic model for autophagy regulation in the Streptomyces S89–F. graminearum inter-kingdom interaction. Acetyltransferase Gcn5 acetylates Atg8 at K13 and retains Atg8 in the nucleus to prevent autophagy under nutrient-rich conditions. Upon co-cultivation with Streptomyces S89 and its secreted rapamycin, or nitrogen starvation, TOR inactivation promotes the degradation of Gcn5 through 26S proteasome, which reduces acetylation level of Atg8. Deacetylated Atg8 is translocated into the cytoplasm and subsequently triggers the autophagic process. Moreover, the lysine deacetylase Hdf1 deacetylates Atg8 and enhances autophagy. Autophagic homeostasis is critical for fungal growth, stress response, and virulence for F. graminearum

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