Fig. 7
From: Gut microbiome variation modulates the effects of dietary fiber on host metabolism
Effects of gut microbiome variation on hepatic gene expression across different fibers. a MA plots showing differentially expressed genes in the liver of mice colonized with SubB vs. SubA microbiome consuming (i) cellulose diet; (ii) inulin diet; (iii) pectin diet; (iv) assorted fiber diet (n = 5 animals/microbiome/diet). Differentially express genes (DEGs) P < 0.05, FDR adjusted-P < 0.05. b Heatmap showing differentially expressed KEGG pathways between SubB and SubA. The ratio of significantly regulated KEGG terms and genes annotated with each KEGG term (minimum of 10) comparing SubB vs. SubA in each dietary intervention are shown in the heatmap. Upregulated pathways are shown in red and downregulated pathways are shown in blue. Inulin and pectin comparisons show the largest number of differentially expressed genes. MA stands for the relationship between values of intensity (i.e., counts) and difference between the data (M = log ratio and A = mean average)