Fig. 4

Same players, different teams. Zi-Pi plots of co-occurrence networks in generalized aggressive periodontitis (a), chronic periodontitis (b), and localized aggressive periodontitis (c). The text box illustrates the general topographical characteristics of each network. The plots show nodes with low connectivity (peripherals), and the putative keystone species, which are separated into local/module key players (module hubs), key players across different modules (connectors), and the combination of the two categories (network hubs). Network graphs of chronic periodontitis and localized aggressive periodontitis (d, e) show the ego network of species that have first-degree edges with the putative keystone species. A similar network graph was not possible for generalized aggressive periodontitis since there no keystone pathogens were identified in the Zi-Pi plot. Nodes are colored based on their modules. Thick edges represent positive correlations, and faint lines represent negative correlations. Data supporting this figure can be found in Supplemental Table 2