Fig. 2

PXR deletion induces sexually dimorphic changes in gut microbiota composition and the hepatic transcriptome. a Unweighted UniFrac multidimensional scaling (MDS) plot based on OTUs (β-diversity). b and c Circular cladogram generated from LEfSe analysis showing the most differentially abundant genera significantly enriched in microbiota from Pxr^+/+ (green) or Pxr^-/- (red) males (b) or females (c). Corresponding LDA scores are presented in Additional file 4F&G. d Venn diagram representing the number of genes overexpressed in the liver from Pxr^-/- vs. Pxr^+/+ mice. e Pathway enrichment analysis of the 15 genes overexpressed in Pxr^-/- vs. Pxr^+/+ males. f Pathway enrichment analysis of the 94 genes overexpressed in Pxr^-/- vs. Pxr^+/+ females. g Venn diagram representing the number of genes underexpressed in the liver from Pxr^-/- vs. Pxr^+/+ mice. h Pathway enrichment analysis of the 743 genes overexpressed in Pxr^-/- vs. Pxr^+/+ females. i Network plot of the enriched terms depicted in (h) colored by cluster ID. j and l Circos plot representing the correlations between caecal bacterial OTUs (blue side quadrant) and hepatic mRNA (green side quadrant) variables in males (j) and females (l). Positive and negative correlations are illustrated with orange and black lines, resp. k and m Relevance network of bacterial OTUs and hepatic transcripts in males (k) and females (m)