Fig. 9

RFI-related microbiota and its association with other microbiota. Difference in RFI between the two groups with the highest and lowest abundance of a duodenal A. muciniphila, b cecal Parabacteroides, c cecal Lactobacillus, d cecal Corynebacterium, e cecal Coprobacillus and f cecal Slackia. Each point represents a sample. The center red point indicates the mean value in the corresponding group and the data are expressed as means ± SD. * and ** indicate adjusted P-values < 0.05 and 0.01. g Spearman’s correlation of specific microbiota among the five sampling sites. Red and blue tiles denote positive and negative correlations for each genus between two different sites, respectively, and a significant r-value is filled in numerically. SI, D, J, I, C and F indicate the small intestine, duodenum, jejunum, ileum, cecum and feces, respectively. h Spearman’s correlation between cecal Lactobacillus and other microbial genera (detected in at least 30% of samples in any of the five sample types). i Relationship between Lactobacillus and the order Clostridiales in the cecum