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Fig. 6 | Microbiome

Fig. 6

From: An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer

Fig. 6

Differential gene expression and pathway analysis of chronic lymphocytic leukemia patients. a Heatmap of all differentially expressed genes (q < 0.05) in tumor tissue samples of chronic lymphocytic leukemia (CLL) patients with (green) and without (orange) detection of Gordonia polyisoprenivorans. Dendrograms show clustering with complete linkage and Euclidian distance measure. b Heatmap of all differentially expressed genes (q < 0.05) in tumor tissue samples of CLL patients with (green) and without (orange) detection of Human Mastadenovirus C. c Boxplots of the distribution of activating versus inhibitory gene t-test statistics for the indicated pathway is shown for tumor tissue samples of CLL patients with (+, n = 23) and without (−, n = 49) detection of Gordonia polyisoprenivorans. The midline of the boxplot shows the median, the box borders show upper and lower quartiles and the whiskers the maximum and minimum test statistic. d Boxplots of the distribution of activating versus inhibitory gene t-test statistics for the indicated pathway is shown for tumor tissue samples of CLL patients with (+, n = 7) and without (−, n = 65) detection of Human Mastadenovirus C. The midline of the boxplot shows the median, the box borders show upper and lower quartiles, and the whiskers the maximum and minimum test statistic. Dendrograms show clustering with complete linkage and Euclidian distance measure

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