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Fig. 5 | Microbiome

Fig. 5

From: An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer

Fig. 5

Patient clusters defined by detected taxa are phenotypically distinct. a CLL patient clusters (1: no specific taxon link, 2: Human Mastadenovirus C, 3: Gordonia polyisoprenivorans) and age (p = 0.0743). b Survival by cluster in CLL (p(1 vs. other) = 0.0246). c Binet stage by detection of Gordonia polyisoprenivorans (p = 0.0252). d TP53 mutation frequency by cluster in CLL (p(cluster 3 vs. other) = 0.0335). e Number of cancer consensus gene mutations by cluster (1: no specific taxon link, 2: Bifidobacterium dentium, 3: Human Herpesvirus 5) in esophageal cancer (p = 0.0858). f Kaplan-Meier survival curves for each cluster in esophageal cancer (p(1 vs. other) = 0.0409). g Liver cancer patient clusters (1: hepatitis B virus, 2: Pseudomonas sp., Serratia sp. and Salmonella enterica, 3: no specific taxon link, 4: Parvibaculum lavamentivorans and Human Herpesvirus 5 in addition to taxa from cluster 2) and age (p = 0.0015). h RNF21 mutation frequency by cluster in liver cancer (p = 0.0121). i KMT2C mutation frequency by cluster (1: no specific taxon link, 2: Cupriavidus metallidurans, 3: no specific taxon link, 4: Methylobacterium populi, 5: Pseudomonas protegens) in pancreatic cancer (p = 0.0308). j CDKN2A mutation frequency by cluster in pancreatic cancer (p = 0.0124). k RNF21 mutation frequency by cluster in pancreatic cancer (p(RNF21) = 0.0107). l Detection of indicated taxa and age in prostate cancer (padj between 0.0015 and 0.0420). m Prostate cancer patient clusters (1: no specific taxon link, 2: Gluconobacter oxydans and Rhodopseudomonas palustris, 3: Pseudomonas sp. TKP, 4: no specific taxon link, 5: Thauera sp. MZ1T, Cupriavidus metallidurans and Pseudomonas mendocina) and age (p = 0.0099). n Link between Propionibacterium acne RPPB and number of cancer consensus gene mutations in prostate cancer (padj = 0.0041). o Kaplan-Meier survival analysis of Ralstonia pickettii detection status in renal cancer (padj = 0.035). p PBRM1 mutation frequency by cluster (1: no specific taxon link, 2: Serratia marcescens) in renal cancer (p = 0.0723). q Pseudomonas sp. TKP detection and age in chronic myeloid dysplasia (padj = 0.039). For all: The midline of the boxplots shows the median, the box borders show upper and lower quartiles, the whiskers show 5th and 95th percentiles and the dots outliers. Only tumor tissues were included in this figure

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