Fig. 6

Continuous co-culture of ΦcrAss002 and Bacteroides xylanisolvens APCS1/XY. a Serial co-culturing of ΦcrAss002 over 30 days. b Serial propagation of the phage on naïve host cells (absent of phage exposure for ~10 generations). c Equivalent experiment using ten B. xylanisolvens cultures with recent phage exposure. ΦcrAss002 titre is shown in copies/ml, determined by absolute qPCR. Statistical analysis was performed by the one-way ANOVA (p < 0.001) with Tukeys as post-test comparing titres. A statistical significance of the difference between the lowest titre and the highest titre sustained shown (p < 0.001***). The arrows indicate the approximate titre ΦcrAss002 at the initiation of each propagation cycle. The error bars represent standard deviation (n = 3)