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Table 2 Fungi-derived compounds and their functions

From: Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

Fungi-derived compounds Functions References
Quorum-sensing molecules Farnesol Filamentous growth and formation ↓
C. albicans biofilm formation ↓
Drug-resistance ↓
Synergy with fluconazole, amphotericin B or micafungin, anti-fungal AMP peptidomimetics, chitosan (CS), and cysteine protease metacaspase
Tyrosol C. albicans biofilm formation ↓
Fungal secondary metabolites Source of antibiotics and immunosuppressant drugs
Hepatotoxicity and/or nephrotoxicity
[54, 92, 93]
Fungi-derived extractives (1,3)/(1,6)-β-glucan Obesity property ↓ [94,95,96,97]
Pyronepolyene C-glucoside iso-D8646-2-6 Influenza A virus (H1N1) infection ↓
Xanthones Virus infection (H1N1, simplex virus types 1 and 2) ↓
Some mangrove-associated or soil-associated fungus-derived compounds Virus infection ↓
Other compounds Candidalysin Systematic infection ↑
Phagocytic clearance ↓
Severity of ethanol-associated hepatitis ↑
Prostaglandins E2 (PGE2) Biofilm formation ↑
Yeast to hyphae transition ↑
C. albicans clearance by phagocytes ↓
Oxylipins Modulating immune responses
  1. “↑” indicates increase and “↓” indicates decrease