Table 2 Fungi-derived compounds and their functions

Quorum-sensing molecules

Farnesol

Filamentous growth and formation ↓

C. albicans biofilm formation ↓

[85,86,87,88,89,90,91]

Drug-resistance ↓

Synergy with fluconazole, amphotericin B or micafungin, anti-fungal AMP peptidomimetics, chitosan (CS), and cysteine protease metacaspase

Tyrosol

C. albicans biofilm formation ↓

Source of antibiotics and immunosuppressant drugs

Hepatotoxicity and/or nephrotoxicity

[54, 92, 93]

Fungi-derived extractives

(1,3)/(1,6)-β-glucan

Obesity property ↓

[94,95,96,97]

Pyronepolyene C-glucoside iso-D8646-2-6

Influenza A virus (H1N1) infection ↓

Xanthones

Virus infection (H1N1, simplex virus types 1 and 2) ↓

Some mangrove-associated or soil-associated fungus-derived compounds

Virus infection ↓

Other compounds

Candidalysin

Systematic infection ↑

Phagocytic clearance ↓

Severity of ethanol-associated hepatitis ↑

[98,99,100,101,102,103,104,105,106,107,108,109,110]

Prostaglandins E2 (PGE2)

Biofilm formation ↑

Yeast to hyphae transition ↑

C. albicans clearance by phagocytes ↓

Oxylipins

Modulating immune responses