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Table 3 Prevalence of genus group present over serial sample collection timepoints in the total bariatric cohort and according to menopausal status, diabetes status and insulin resistance status

From: The association between obesity and weight loss after bariatric surgery on the vaginal microbiota

  Lactobacillus dominant
n/N (%)
Gardnerella dominant
n/N (%)
High diversity
n/N (%)
Total
n/N (%)
Total bariatric surgery cohort
 Baseline (day of surgery) (n=27) 10/27 (37.0) 5/27 (18.6) 12/27 (44.4) 27/27 (100)
 3 months post-surgery (n=22) 7/22 (31.8) 6/22 (27.3) 9/22 (40.9) 22/22 (100)
 6 months post-surgery (n=19) 10/19 (52.6) 2/19 (10.5) 7/19 (36.9) 19/19 (100)
 Total (n=84) 31/84 (36.9) 16/84 (19.1) 37/84 (44.0) 84/84 (100)
p valuea     0.506
Pre-menopausal women only
 Baseline (day of surgery) (n=17) 6/17 (35.3) 4/17 (23.5) 7/17 (41.2) 17/17 (100)
 3 months post-surgery (n=15) 5/15 (33.3) 4/15 (26.7) 6/15 (40.0) 15/15 (100)
 6 months post-surgery (n=14) 8/14 (57.1) 2/14 (14.3) 4/14 (28.6) 14/14 (100)
 Total (n=58) 22/58 (37.9) 12/58 (20.7) 24/58 (41.4) 58/58 (100)
p value     0.572
Post-menopausal women only
 Baseline (day of surgery) (n=10) 4/10 (40.0) 1/10 (10.0) 5/10 (50.0) 10/10 (100)
 3 months post-surgery (n=7) 2/7 (28.6) 2/7 (28.6) 3/7 (42.8) 7/7 (100)
 6 months post-surgery (n=5) 2/5 (40.0) 0/5 (0) 3/5 (60.0) 5/5 (100)
 Total (n=26) 9/26 (34.6) 4/26 (15.4) 13/26 (50.0) 26/26 (100)
p value     0.999
Non-diabetic women only
 Baseline (day of surgery) (n=19) 6/19 (31.6) 3/19 (15.8) 10/19 (52.6) 19/19 (100)
 3 months post-surgery (n=16) 6/16 (37.5) 4/16 (25.0) 6/16 (37.5) 16/16 (100)
 6 months post-surgery (n=14) 8/14 (57.1) 1/14 (7.2) 5/14 (35.7) 14/14 (100)
 Total (n= 58) 21/58 (36.2) 9/58 (15.5) 28/58 (48.3) 58/58 (100)
p value     0.572
Diabetic women only
 Baseline (day of surgery) (n=8) 4/8 (50.0) 2/8 (25.0) 2/8 (25.0) 8/8 (100)
 3 months post-surgery (n=6) 1/6 (16.7) 2/6 (33.3) 3/6 (50.0) 6/6 (100)
 6 months post-surgery (n=5) 2/5 (40.0) 1/5 (20.0) 2/5 (40.0) 5/5 (100)
 Total (n=26) 10/26 (38.5) 7/26 (26.9) 9/26 (34.6) 26/26 (100)
p value**     n/a
Women without insulin resistancec
 Baseline (day of surgery) (n=4) 1/4 (25.0) 1/4 (25.0) 2/4 (50.0) 4/4 (100)
 3 months post-surgery (n=2) 0/2 (0) 0/2 (0) 2/2 (100) 2/2 (100)
 6 months post-surgery (n=7) 4/7 (57.1) 1/7 (14.3) 2/7 (28.6) 7/7 (100)
 Total (n=13) 5/13 (38.5) 2/13 (15.4) 6/13 (46.1) 13/13 (100)
p value     n/a
Women with insulin resistance
 Baseline (day of surgery) (n=5) 2/5 (40.0) 1/5 (20.0) 2/5 (40.0) 5/5 (100)
 3 months post-surgery (n=1) 0/1 (0) 0/1 (0) 1/1 (100) 1/1 (100)
 6 months post-surgery (n=1) 1/1 (100) 0/1 (0) 0/1 (0) 1/1 (100)
 Total (n=7) 3/7 (42.9) 1/7 (14.3) 3/7 (42.9) 7/7 (100)
p valueb     n/a
  1. aA p value of less than 0.05 demonstrates a significant difference between the proportion (%) of genus group present (Lactobacillus-dominant, Gardnerella-dominant or high diversity VMB) over serial timepoints 0 to 6 months (McNemar’s Chi-square test)
  2. bSample size too small to compute p value using McNemar’s Chi-square test
  3. cWhere concomitant fasting serum samples were available, fasting glucose and fasting insulin levels were identified. Using these values, we were able to calculate the HOMA-IR, according to the following formula: the product of fasting insulin (μU/L) multiplied by fasting glucose (nmol/L) divided by 22.5. The 2nd tertile was used as the cut-off to determine insulin resistance status. Insulin resistance cut-off value: 2.98