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Fig. 5 | Microbiome

Fig. 5

From: Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity

Fig. 5

Fecal virus species correlated with COVID-19 severity and blood parameters. a Recruited COVID-19 patients and their symptom severity. Patients were separated in to non-severe (n=56) and moderate/severe (n=42) groups. b–f Blood measurement results for LDH, C-reactive protein, neutrophil count, ALT, and albumin concentrations. Data are shown in mean ± s.e. The comparisons were made between non-severe and moderate/severe groups via Mann-Whitney test. g–i The abundance of pepper chlorotic spot virus in fecal RNA virome and its association with disease severity (g), blood concentrations of LDH (h), and C-reactive protein (i). CPM, count per million reads. Between-two group comparison was conducted by Mann-Whitney test. Correlation test was performed by Spearman correlation test. j, k The 9 DNA virus species that negatively correlated with severity of COVID-19 (j) and their correlations with blood measurements (k). Correlation test was performed by Spearman correlation test. k The color and intensity denote the spearman correlation direction and coefficient, where only the significant correlations with blood parameters of |correlation coefficient| > 0.3 were shown

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