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Fig. 3 | Microbiome

Fig. 3

From: Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity

Fig. 3

Temporal changes in the gut DNA virome in COVID-19 patients during disease course. a Temporal changes of the differential species shown in Fig. 2d in each COVID-19 patient over the disease course. b Temporal dissimilarity of patient’s fecal DNA virome to non-COVID-19 fecal DNA viromes over the disease course. Virome dissimilarity of the patient to non-COVID-19 subjects was plotted as the average Bray-Curtis dissimilarity between the indicated fecal virome to all non-COVID-19 viromes. The gray area depicts the dissimilarity range (mean ± s.e.) between non-COVID-19 fecal DNA viromes (the dashed line denotes the mean dissimilarity). “CoV n” denotes COVID-19 patient number. “Day0” denotes baseline date when the first stool was collected after hospitalization; the following time points starting with “Day” represents days since baseline stool collection. Patients labeled with an asterisk were patients who had persisted altered virome after disease resolution. c The average (median) Bray-Curtis dissimilarity of patient fecal DNA viromes to non-COVID-19 fecal DNA viromes during the disease course. For box plots, the boxes extend from the 1st to 3rd quartile (25th to 75th percentile), with the median depicted by a horizontal line. Statistical significance was determined by Mann-Whitney test, ****p<0.0001, **p<0.01

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