Whole population (n = 17) | Sham transplantation (n = 9) | Fecal transplantation (n = 8) | p value (sham vs FMT) | |
---|---|---|---|---|
Age (years) | 34.0 [29.0; 37.0] | 34.0 [33.0; 52.0] | 31.5 [27.5; 36.5] | 0.10 |
Male | 9 (52.9) | 4 (44.4) | 5 (62.5) | 0.64 |
Female | 8 (47.1) | 5 (55.6) | 3 (37.5) | |
BMI (kg/m2) | 22.3 [19.8; 23.3] | 22.7 [22.3; 23.3] | 21.0 [18.6; 22.9] | 0.15 |
Smoking, never/past/active | 6 (35.3)/6 (35.3)/5 (29.4) | 3 (33.3)/4 (44.4)/2 (22.2) | 3 (37.5)/2 (25.0)/3 (37.5) | 0.7 |
Disease duration (years) | 9 [5; 15] | 11 [8; 15] | 8.5 [4; 12.8] | 0.19 |
Montreal, L2/L3 | 7 (41.2)/10 (58.8) | 5 (55.6)/4 (44.4) | 2 (25.0)/6 (75.0) | 0.33 |
Hemoglobin (g/L) | 138 [121; 142] | 138 [121; 142] | 134 [116; 147] | 0.46 |
White cell count (109/L) | 10.9 [9.3; 12.8] | 12.4 [10.0; 13.3] | 10.1 [8.6; 11.3] | 0.06 |
Platelet (109/L) | 338.0 [278.0; 405.0] | 346.0 [280.0; 385.0] | 292.5 [275.5; 493.5] | 0.42 |
CRP (mg/L) | 3.0 [3.0; 3.1] | 3.0 [3.0; 4.2] | 3.0 [3.0; 3.0] | 0.31 |
Albumin (g/L) | 40.7 [39.4; 42.7] | 40.5 [39.4; 42.5] | 41.4 [39.6; 44.0] | 0.27 |
Fecal calprotectin (ug/g) | 102.0 [40.0; 157.0] | 117.0 [45.0; 177.3] | 53.5 [38.0; 112.0] | 0.22 |
Previous azathioprine treatment | 10 (58.8) | 6 (66.6) | 4 (50.0) | 0.49 |
Previous anti-TNF therapy | 5 (29.4) | 3 (33.3) | 2 (25.0) | 0.71 |
Previous other biological therapy | 3 (17.7) | 2 (22.2) | 1 (12.5) | 0.60 |
History of intestinal resection | 2 (11.8) | 1 (11.1) | 1 (12.5) | 0.92 |
HBI score | 2.0 [0.0; 3.0] | 2.0 [0.0; 3.0] | 1.5 [0.5; 2.5] | 0.35 |
CDAI score | 62.0 [41.0; 109.0] | 54.0 [35.0 ; 103.0] | 65.5 [51.5; 173.5] | 0.16 |
CDEIS score | 4.6 [0.2; 10.5] | 1.6 [0.0; 6.0] | 7.1 [3.5; 12.2] | 0.062 |