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Table 1 Characteristics of patients at baseline (time of intervention)

From: Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study

 

Whole population (n = 17)

Sham transplantation (n = 9)

Fecal transplantation (n = 8)

p value (sham vs FMT)

Age (years)

34.0 [29.0; 37.0]

34.0 [33.0; 52.0]

31.5 [27.5; 36.5]

0.10

 Male

9 (52.9)

4 (44.4)

5 (62.5)

0.64

 Female

8 (47.1)

5 (55.6)

3 (37.5)

BMI (kg/m2)

22.3 [19.8; 23.3]

22.7 [22.3; 23.3]

21.0 [18.6; 22.9]

0.15

 Smoking, never/past/active

6 (35.3)/6 (35.3)/5 (29.4)

3 (33.3)/4 (44.4)/2 (22.2)

3 (37.5)/2 (25.0)/3 (37.5)

0.7

 Disease duration (years)

9 [5; 15]

11 [8; 15]

8.5 [4; 12.8]

0.19

 Montreal, L2/L3

7 (41.2)/10 (58.8)

5 (55.6)/4 (44.4)

2 (25.0)/6 (75.0)

0.33

Hemoglobin (g/L)

138 [121; 142]

138 [121; 142]

134 [116; 147]

0.46

White cell count (109/L)

10.9 [9.3; 12.8]

12.4 [10.0; 13.3]

10.1 [8.6; 11.3]

0.06

Platelet (109/L)

338.0 [278.0; 405.0]

346.0 [280.0; 385.0]

292.5 [275.5; 493.5]

0.42

CRP (mg/L)

3.0 [3.0; 3.1]

3.0 [3.0; 4.2]

3.0 [3.0; 3.0]

0.31

Albumin (g/L)

40.7 [39.4; 42.7]

40.5 [39.4; 42.5]

41.4 [39.6; 44.0]

0.27

Fecal calprotectin (ug/g)

102.0 [40.0; 157.0]

117.0 [45.0; 177.3]

53.5 [38.0; 112.0]

0.22

Previous azathioprine treatment

10 (58.8)

6 (66.6)

4 (50.0)

0.49

Previous anti-TNF therapy

5 (29.4)

3 (33.3)

2 (25.0)

0.71

Previous other biological therapy

3 (17.7)

2 (22.2)

1 (12.5)

0.60

History of intestinal resection

2 (11.8)

1 (11.1)

1 (12.5)

0.92

HBI score

2.0 [0.0; 3.0]

2.0 [0.0; 3.0]

1.5 [0.5; 2.5]

0.35

CDAI score

62.0 [41.0; 109.0]

54.0 [35.0 ; 103.0]

65.5 [51.5; 173.5]

0.16

CDEIS score

4.6 [0.2; 10.5]

1.6 [0.0; 6.0]

7.1 [3.5; 12.2]

0.062

  1. Categorical parameters indicated as n (%) and continuous values indicated as P50 [P25; P75]. Quantitative variables were compared using a non-parametric Wilcoxon rank-sum tests. Qualitative variables were compared using Fisher’s exact test
  2. BMI body mass index, CRP C reactive protein, HBI Harvey Bradshaw Index, CDAI Crohn’s disease activity index, CDEIS Crohn’s Disease Endoscopic Index of Severity