Table 5 List of pathways significantly enriched by the list of regulators

Osteoarthritis pathway

3.13

0.019

RUNX2,SMAD4,SOX9,TCF4

TGF-β signaling

3.07

0.031

RUNX2,SMAD4,TFE3

Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis

3.07

0.018

NFATC3,RUNX2,SMAD4,TCF4

Glucocorticoid receptor signaling

2.4

0.012

NCOR1,NFATC3,SMAD4,STAT1

VDR/RXR activation

2

0.022

NCOR1,RUNX2

BMP signaling pathway

1.93

0.024

RUNX2,SMAD4

Colorectal cancer metastasis signaling

1.89

0.012

SMAD4,STAT1,TCF4

Regulation of IL-2 expression in activated and anergic T lymphocytes

1.89

0.023

NFATC3,SMAD4

Senescencepathway

1.79

0.011

ELF2,NFATC3,SMAD4

Mouse embryonic stem cell pluripotency

1.77

0.019

SMAD4,TCF4

Pancreatic adenocarcinoma signaling

1.72

0.018

SMAD4,STAT1

Neuroinflammation signaling pathway

1.69

0.010

NFATC3,NFE2L2,STAT1

Th1 pathway

1.64

0.016

NFATC3,STAT1

Human embryonic stem cell pluripotency

1.55

0.015

SMAD4,TCF4

Aryl hydrocarbon receptor signaling

1.5

0.014

NFE2L2,TP73

Factors promoting cardiogenesis in vertebrates

1.47

0.013

SMAD4,TCF4

HOTAIR regulatory pathway

1.41

0.012

KMT2C,TCF4

Protein kinase A signaling

1.38

0.008

NFATC3,SMAD4,TCF4

Th1 and Th2 activation pathway

1.36

0.013

NFATC3,STAT1

Wnt/β-catenin signaling

1.35

0.012

SOX9,TCF4

T cell exhaustion signaling pathway

1.34

0.011

NFATC3,STAT1

IL-22 signaling

1.34

0.042

STAT1

Role of JAK family kinases in IL-6-type cytokine signaling

1.32

0.040

STAT1

ERK/MAPK signaling

1.3

0.010

ELF2,STAT1

Hepatic fibrosis/hepatic stellate cell activation

1.3

0.011

SMAD4,STAT1