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Fig. 3 | Microbiome

Fig. 3

From: Antibiotic-associated dysbiosis affects the ability of the gut microbiota to control intestinal inflammation upon fecal microbiota transplantation in experimental colitis models

Fig. 3

Metabolomics analysis and co-occurrence of the gut microbiota with microbiota-derived metabolites in DSS colitic recipients after FMT with antibiotics pre-conditioned microbiota. a Partial least square discriminant analysis showing clustered samples according to the type of antibiotic treatment. b Metabolites that differentiate samples according to treatment with a variable important in projection (VIP) score > 2. c Metabolites with the highest discriminative power for the classification of samples (VIP score > 2) according to treatment. *p < 0.05, **p < 0.01, *** < 0.001; Wilcoxon rank-sum test. d Heatmap of Spearman’s ρ (ρs) correlations between the relative abundance of the most represented bacterial genera (with relative abundance > 0.1%) in the gut microbiota of colitic animals after treatments with the metabolites with the highest discriminatory power. The significant correlations with an FDR-corrected p < 0.05 are indicated with an asterisk (*)

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