TY - JOUR AU - Petruschke, Hannes AU - Schori, Christian AU - Canzler, Sebastian AU - Riesbeck, Sarah AU - Poehlein, Anja AU - Daniel, Rolf AU - Frei, Daniel AU - Segessemann, Tina AU - Zimmerman, Johannes AU - Marinos, Georgios AU - Kaleta, Christoph AU - Jehmlich, Nico AU - Ahrens, Christian H. AU - von Bergen, Martin PY - 2021 DA - 2021/02/23 TI - Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome JO - Microbiome SP - 55 VL - 9 IS - 1 AB - The intestinal microbiota plays a crucial role in protecting the host from pathogenic microbes, modulating immunity and regulating metabolic processes. We studied the simplified human intestinal microbiota (SIHUMIx) consisting of eight bacterial species with a particular focus on the discovery of novel small proteins with less than 100 amino acids (= sProteins), some of which may contribute to shape the simplified human intestinal microbiota. Although sProteins carry out a wide range of important functions, they are still often missed in genome annotations, and little is known about their structure and function in individual microbes and especially in microbial communities. SN - 2049-2618 UR - https://doi.org/10.1186/s40168-020-00981-z DO - 10.1186/s40168-020-00981-z ID - Petruschke2021 ER -