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Table 2 Glucose and hormonal excursions in an oral glucose tolerance test after the intervention

From: High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

  Placebo Saccharin Lactisole Sac + Lac ANCOVA P
Glucose (AUC) 7136.4 ± 943.6 6606.9 ± 951.7 7571.0 ± 1289.2 6203.8 ± 1084.2 0.6018
Insulin (AUC) 362518.7 ± 55694.9 476124.6 ± 77735.0 412000.5 ± 69663.6 299078.8 ± 41026.4 0.7627
C peptide (AUC) 645605.0 ± 73479.8 747311.4 ± 68855.8 677199.5 ± 61852.4 525798.3 ± 28535.9 0.6034
Glucagon (AUC) − 3993.5 ± 771.9 − 3226.6 ± 1306.1 − 3768.0 ± 984.4 − 4504.1 ± 1528.9 0.8632
GLP1 (AUC) 2734.8 ± 983.2 2195.4 ± 410.7 2294.1 ± 384.5 1862.9 ± 520.9 0.0662
  1. All values are mean ± SEM. Treatment effects between groups were assessed by ANCOVA using the baseline glucose tolerance test AUC as a covariate