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Table 2 Glucose and hormonal excursions in an oral glucose tolerance test after the intervention

From: High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

 

Placebo

Saccharin

Lactisole

Sac + Lac

ANCOVA P

Glucose (AUC)

7136.4 ± 943.6

6606.9 ± 951.7

7571.0 ± 1289.2

6203.8 ± 1084.2

0.6018

Insulin (AUC)

362518.7 ± 55694.9

476124.6 ± 77735.0

412000.5 ± 69663.6

299078.8 ± 41026.4

0.7627

C peptide (AUC)

645605.0 ± 73479.8

747311.4 ± 68855.8

677199.5 ± 61852.4

525798.3 ± 28535.9

0.6034

Glucagon (AUC)

− 3993.5 ± 771.9

− 3226.6 ± 1306.1

− 3768.0 ± 984.4

− 4504.1 ± 1528.9

0.8632

GLP1 (AUC)

2734.8 ± 983.2

2195.4 ± 410.7

2294.1 ± 384.5

1862.9 ± 520.9

0.0662

  1. All values are mean ± SEM. Treatment effects between groups were assessed by ANCOVA using the baseline glucose tolerance test AUC as a covariate