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Fig. 2 | Microbiome

Fig. 2

From: High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

Fig. 2

Effects of saccharin treatment on glucose homeostasis in mice. a Glucose responses during an i.g.GTT expressed as area under curve (AUC) before 0 week, 2 and 10 weeks after water or saccharin treatment in WT and T1R2-KO (T1R2) mice. Two-way ANOVA main genotype effect, p < 0.0001; p values of post hoc test. b Glucose excursions during an i.g.GTT after 10 weeks of water or saccharin treatment. Two-way ANOVA repeated measures, p value of main genotype effect. c Ex vivo glucose flux using 3-O-methy-glucose (3-OMG) in intact mouse intestines following 10 weeks of water or saccharin treatment. Two-way ANOVA, p value of main genotype effect. d Ex vivo intestinal permeability assessed by FITC-dextran (4 kDa) flux in intact mouse intestines following 10 weeks of water or saccharin treatment. Two-way ANOVA, p value of main treatment effect. For mouse in vivo studies (n = 23–28/group), for ex vivo studies (n = 6–11/group)

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Microbiome

ISSN: 2049-2618

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