Unmasking viral sequences by metagenomic next-generation sequencing in adult human blood samples during steroid-refractory/dependent graft-versus-host disease

Table 2 Clinical characteristics of 7 patients with clinically unrecognized viral sequences

Patient’s code	Age, gender	Underlying disease	GvHD organ	GvHD treatments^a	Outcome
Ge02	61, M	Lymphoma	Digestive, skin	CSA, tacrolimus, corticosteroids, sirolimus, budenoside, photopheresis	Death (GvHD-related)
Ge05	23, M	Lymphoma	Digestive, skin, lung	CSA, MMF, tacrolimus, corticosteroids	Death
Ge07	60, M	ALL	Digestive	Tacrolimus, corticosteroids, photopheresis	Death
Ge09	65, M	AML	Liver, digestive^b	CSA, corticosteroids, tocilizumab	Death
Ge12	44, M	MM	Digestive, liver	CSA, corticosteroids, basiliximab, MMF	Death
Ge14	31, M	AML	Digestive, liver	Corticosteroids	Death
Ge22	68, M	MDPS	Digestive, skin	CSA, tacrolimus, corticosteroids, vedolisumab, prolastin	Death

Age at the time of transplantation
Abbreviations: GvHD graft-versus-host disease, M male, ALL acute lymphoid leukemia, AML acute myeloid leukemia, MM multiple myeloma, MDPS myelodysplasic proliferative syndrome, CSA cyclosporine A, MMF mycophenolate mofetil
^aAll patients had ruxolitinib as part of the GvHD treatment
^bDigestive GvHD was not confirmed by biopsies

ISSN: 2049-2618