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Table 2 Clinical characteristics of 7 patients with clinically unrecognized viral sequences

From: Unmasking viral sequences by metagenomic next-generation sequencing in adult human blood samples during steroid-refractory/dependent graft-versus-host disease

Patient’s code Age, gender Underlying disease GvHD organ GvHD treatmentsa Outcome
Ge02 61, M Lymphoma Digestive, skin CSA, tacrolimus, corticosteroids, sirolimus, budenoside, photopheresis Death (GvHD-related)
Ge05 23, M Lymphoma Digestive, skin, lung CSA, MMF, tacrolimus, corticosteroids Death
Ge07 60, M ALL Digestive Tacrolimus, corticosteroids, photopheresis Death
Ge09 65, M AML Liver, digestiveb CSA, corticosteroids, tocilizumab Death
Ge12 44, M MM Digestive, liver CSA, corticosteroids, basiliximab, MMF Death
Ge14 31, M AML Digestive, liver Corticosteroids Death
Ge22 68, M MDPS Digestive, skin CSA, tacrolimus, corticosteroids, vedolisumab, prolastin Death
  1. Age at the time of transplantation
  2. Abbreviations: GvHD graft-versus-host disease, M male, ALL acute lymphoid leukemia, AML acute myeloid leukemia, MM multiple myeloma, MDPS myelodysplasic proliferative syndrome, CSA cyclosporine A, MMF mycophenolate mofetil
  3. aAll patients had ruxolitinib as part of the GvHD treatment
  4. bDigestive GvHD was not confirmed by biopsies