Fig. 5

Impact on autoimmune hyperthyroidism and orbitopathy and total disease outcomes of gut microbiota modifications. a Percentages of positive untreated TSHR-immunized mice set to 100% and the changes of positivity in the treated groups Lab4, hFMT or vancomycin were calculated. Changes in positive mice are given in % relative to untreated TSHR-immunized mice. Parameters were normalized using the Z-Score (see the “Materials and methods” section). b Z-Score of autoimmune hyperthyroidism includes values of TSAbs and T4. c Z-Score of orbitopathy evaluated by BAT and atrophic fibers. Data are presented as mean ± standard error of the mean. Statistical analysis was performed by two-way-ANOVA; multiplicity adjusted P values are given as follows: *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. d, e Disease classification was based on Z-score values. The number of mice is given in %, see STAR methods for classification parameters. Additionally, the number of mice in each category is shown in Table S2