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Table 1 Predicted KEGG functional pathway differences at level 2 inferred from 16S rRNA gene sequences using PICRUSt after chronic HFFD diet with or without β-glucan supplementation

From: β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

KO functional categories      
Level_1 Level_2 Con mean% (SD%) HFFD mean% (SD%) HFBG mean% (SD%) Con vs HFFD p value HFBG vs HFFD p value
Cellular processes Cell motility 3.491 (0.316) 4.891 (0.530) 3.084 (1.207) 0.008 _
Cellular processes Cell growth and death 0.583 (0.013) 0.559 (0.026) 0.596 (0.055) _ 0.019
Cellular processes Transport and catabolism 0.585 (0.042) 0.419 (0.028) 0.626 (0.065) 0.008 0.016
Genetic information processing Translation 6.214 (0.205) 5.767 (0.271) 6.503 (0.645) _ 0.032
Genetic information processing Transcription 3.149 (0.085) 3.526 (0.108) 2.943 (0.388) 0.015 _
Genetic information processing Folding, sorting, and degradation 2.675 (0.074) 2.475 (0.157) 2.778 (0.333) _ 0.016
Environmental information processing Signal transduction 2.123 (0.083) 2.694 (0.130) 2.000 (0.328) 0.012 0.032
Metabolism Amino acid metabolism 11.09 (0.226) 10.490 (0.370) 11.311 (0.750) _ 0.032
Metabolism Energy metabolism 6.565 (0.169) 6.134 (0.325) 6.812 (0.684) _ 0.016
Metabolism Metabolism of cofactors and vitamins 4.793 (0.117) 4.618 (0.177) 4.915 (0.404) _ 0.016
Metabolism Glycan biosynthesis and metabolism 3.402 (0.204) 2.666 (0.137) 3.592 (0.430) 0.008 0.016
Metabolism Xenobiotics biodegradation and metabolism 1.787 (0.051) 1.929 (0.028) 1.724 (0.087) 0.016 0.001
Human diseases Neurodegenerative diseases 0.175 (0.007) 0.181 (0.008) 0.172 (0.004) 0.027 0.032
Organismal systems Environmental adaptation 0.186 (0.011) 0.218 (0.005) 0.177 (0.015) 0.016 0.032
Cellular processes Cell motility 3.491 (0.316) 4.891 (0.530) 3.084 (1.207) 0.008 _
Cellular processes Cell growth and death 0.583 (0.013) 0.559 (0.026) 0.596 (0.055) _ 0.019
  1. Note: Data are given as mean% (SD%). KEGG Kyoto Encyclopedia of Genes and Genomes, PICRUSt Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, KO KEGG Ortholog, SD standard deviation