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Fig. 5 | Microbiome

Fig. 5

From: β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

Fig. 5

Long-term β-glucan supplementation prevented gut microbiota alteration in HFFD-induced obese mice. Cecal contents microbiota composition was analyzed by 16S rRNA gene sequencing (n = 4–5). a Principal coordinates analysis plot of unweighted UniFrac distances. b Composition of abundant bacterial phyla. c Comparison of the representative taxonomic abundance among Con, HFFD, and HFBG groups at phylum. d and e Linear discriminant analysis (LDA) effect size showing the most differentially significant abundant taxa enriched in microbiota from the Con vs. HFFD as well as HFBG vs. HFFD. fi Comparison of the representative taxonomic abundance of Bacteroidetes among Con, HFFD, and HFBG groups at class (g), order (h), family (i), and genus (j). Values are mean ± SEM. *p < 0.05 vs. Control (Con). #p < 0.05 vs. high-fat and fiber-deficient (HFFD). Abbreviations: p, phylum; c, class; o, order; f, family; g, genus

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