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Fig. 2 | Microbiome

Fig. 2

From: β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

Fig. 2

Long-term β-glucan supplementation suppressed the microglia activation and inflammation in the hippocampus of HFFD-induced obese mice. a The protein level of Iba1 in the hippocampus (n = 6). b The immunofluorescent staining of Iba1 in CA1, CA3, and DG of the hippocampus (n = 6) (scale bar 50 μm). The image captured from the box was marked with a dotted line (scale bar 10 μm). c The orthogonal view of the high-resolution confocal image shows the colocalization of Iba1 (green) and PSD95 (red) (scale bar 5 μm). de The mRNA expression of pro-inflammatory cytokines, TNFα, IL-1β, and IL-6 in the hippocampus (n = 5–6). Values are mean ± SEM. *p < 0.05 vs. control (Con). #p < 0.05 vs. high-fat and fiber-deficient (HFFD)

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