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Fig. 1 | Microbiome

Fig. 1

From: Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

Fig. 1

Associations of gut microbiota composition with gender and menopause status. (a) Alpha diversity indices (n = 131). (b) Beta diversity measured by Bray Curtis and weighted unifrac. Overall differences in the microbiome composition among groups were assessed by PERMANOVA using 1000 permutations and pairwise differences between groups were assessed using the pairwise.adonis function adjusted for Bonferroni correction. *p < 0.05. (c) Volcano plot of differential bacterial abundance analysis between pre-menopausal women and men, (d) post-menopausal women and men, and (e) pre- and post-menopausal women, as calculated by DESeq2 from shotgun metagenomic sequencing, adjusting for age and obesity status. For each taxa, the fold change and the p values corrected for multiple comparisons by the Benjamini-Hochberg procedure (pFDR) are plotted. Significantly different taxa (FC > 1.5 and pFDR < 0.05) are colored according to phylum

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