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Fig. 4 | Microbiome

Fig. 4

From: Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery

Fig. 4

Distinct microbiome signatures were found between low- and high-TMAO producing status. a For all the 56 healthy subjects, the 16S rRNA gut microbial profiles did not show a significant change between pre- and post-carnitine supplementation. b When the samples were regrouped based on the status of TMAO productivity (i.e., TMAOMAX < 10 μM vs. TMAOMAX > 10 μM), the 16S rRNA gut microbial profiles exhibited a significant difference between low- and high-TMAO producers (p < 0.001, R2 0.027). c The relative abundance of E. timonensis was significantly enriched in high-TMAO producers than low-TMAO producers. Data were analyzed by paired Wilcoxon test; bars represent the mean ± S.E.M for the indicated groups. d The relative abundance of E. timonensis was significantly correlated to the TMAO productivity. e The E. timonensis was present in 13 of 51 samples of high-TMAO producing status while it was absent in all 61 samples of low-TMAO producing status, contributing to a sensitivity of 25.5% with 100% specificity for detecting high-TMAO producers

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