Fig. 3

Metabolic capabilities of Bradymonabacteria. Metabolic predictions were mainly generated by referring to the KEGG and SEED database interface. Each subgroup of Bradymonabacteria is depicted as a colored circle (see figure legend). Functional genes (abbreviation according to KEGG) encoding the relevant proteins/enzymes are labeled for each metabolic step where colored circles (that is, Bradymonabacteria strains) are depicted to show the potential functions of each subgroup if any. The gray arrows indicate the corresponding genes detected for the pathways in almost all the genomes, while the red arrows indicate the corresponding genes missing from the pathways. The red “no entry” signs indicate the many key genes in pathways that are missing. All putative transporters and F0F1 ATPases are shown as well as secretion systems, type IV pili, and predicted components of flagella. The process of starvation and stringent-responsive system remodeling is mediated by the production of the alarmones guanosine pentaphosphate, pppGpp, and guanosine tetraphosphate, ppGpp. The key metabolic predictions are supported by the gene information in Table S2