Immunoglobulin recognition of fecal bacteria in stunted and non-stunted children: findings from the Afribiota study

Table 1 Demographics of stunted and non-stunted children with valid IgA-seq data (N = 138)

Description	Non-stunted (N = 67)	Stunted (N = 71)	P
Country
Madagascar	35/67 (52.2%)	43/71 (60.6%)	0.3909
Central African Republic (CAR)	32/67 (47.8%)	28/71 (39.4%)
Sex
Male	29/67 (43.3%)	35/71 (49.3%)	0.4993
Female	38/67 (56.7%)	36/71 (50.7%)
Age
Median (months)	42.7	38.4	0.3553
2–3 years	24/67 (35.8%)	30/71 (42.2%)
3–4 years	18/67 (26.9%)	17/71 (23.9%)
4–5+ years	25/67 (37.3%)	24/71 (33.8%)
Nutritional status
Median HAZ score	− 1.05	− 3.48	2.2e−16
Median WHZ score	− 0.21	− 0.54	0.0600
Median hemoglobin (g/100 mL serum)	11.6	10.9	0.0040
Presence of anemia	18/64 (28.1%)	34/66 (51.5%)	0.0076
Breastfeeding
Median duration (months)	20	20	0.8842
Inflammation			0.4979
Median AAT (mg/g dry fecal weight)	42.0	43.5
Median calprotectin (μg/g dry fecal weight)	367.5	405.0	0.7026
Elevated CRP (> 10 mg/l serum)	4/61 (6.5%)	13/66 (19.7%)	0.0374
Parasites
Presence of helminths	34/59 (57.6%)	36/66 (54.5%)	0.8569
Presence of Giardia	11/59 (18.6%)	17/66 (25.7%)	0.3942
Sequencing batch
Batch 1	26/67 (38.8%)	27/71 (38.0%)	1.000
Batch 2	41/67 (61.2%)	44/71 (62.0%)

Values are presented as the group median (continuous variable) or as counts (categorical variable) with missing values excluded. Significance was determined by Wilcoxon rank sum test (continuous variable) or Fisher’s exact test (categorical variable). Hemoglobin was adjusted by altitude (− 0.2 g/100 mL in Madagascar to account for the height above sea level). Anemia was defined as an adjusted hemoglobin level below 11 g/100 mL. Elevated CRP was defined as > 10 mg/l serum. Breastfeeding duration represents the total number of months a child was previously breastfed for; all but four children had been weaned by the time of sampling

ISSN: 2049-2618