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Fig. 3 | Microbiome

Fig. 3

From: Immunoglobulin recognition of fecal bacteria in stunted and non-stunted children: findings from the Afribiota study

Fig. 3

Distribution of IgA-targeting by study metadata. a Principal coordinate analysis based on Euclidian distance of the IgA Index, colored by country of origin. b Summary of PERMANOVA analysis of the IgA Index in the full dataset (All) and in each country individually. Analysis is based on taxa maintained at the ASV level. Starred variables are significant with an FDR-corrected p < 0.05. Each variable was tested individually in the PERMANOVA without other covariates. CAR, Central African Republic; Mada, Madacascar; Coef, the coefficient of variance by PERMANOVA. Briefly, the tested variables were as follows: whz_cont, weight-for-height z-score; total IgA, total fecal IgA (ng/g of feces, wet weight); percent IgA+, the percentage of IgA+ bacteria by flow cytometry; helminth, presence or absence of helminths; haz, height-for-age z-score; depth, the relative sequencing depth of the IgA+ fraction compared to the IgA− fraction of a given sample; crp, serum c-reactive protein in mg/l; calprotectin, fecal calprotectin in μg/g dry weight; breastfeeding, total duration of breastfeeding in months; batch, sequencing batch; anemia, presence or absence of anemia; age, child’s age in months; aat, fecal alpha-1 antitrypsin in mg/g dry weight. N = 138 total; N = 78 in Madagascar and N = 60 in CAR

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