Fig. 2

Highly IgA-targeted taxa at genus level. a IgA-targeting profiles at genus level in the full dataset (All), Madagascar (Mada), and Central African Republic (CAR). Genera are included if the IgA Index was significantly different from zero by a one-sided Wilcoxon (FDR-adjusted p < 0.05) in at least one subset. Color of circles indicates the direction of IgA-targeting (red = positive IgA Index, blue = negative IgA Index), and saturation of the color represents FDR-corrected statistical significance. The size of the circle indicates overall effect size as measured by average IgA Index. b–d Most highly IgA-targeted taxa in b the full dataset, c Madagascar, and d CAR, as defined by a median IgA Index greater than zero with FDR-adjusted p < 0.05. N = 138 total children; N = 78 in Madagascar and N = 60 in CAR