Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment

Fig. 1

Effects of young adult and elderly feces on the occurrence of cognitive impairment and colitis in the transplanted mice. Effects on the occurrence of cognitive impairment in Y-maze (A), NOR (B), and Barnes maze tasks (C). Effects on the BDNF+/NeuN+ (D), NF-κB+/Iba1+ (E), and LPS+/Iba1+ cell populations (F) in the hippocampus. G Effects on the BDNF expression and NF-κB activation in the hippocampus. H Effects on the IL-1β expression in the hippocampus, assessed by ELISA. Effects on the colon length (I), myeloperoxidase (MPO) activity (J), IL-1β expression (K), NF-κB activation, p16 expression (L), and NF-κB+/CD11c+ cell population (M) in the colon. Fecal transplantations of young adults (YF) and elderly people (AF) were orally gavaged once a day for 5 days. Control mice (NC) were treated with vehicle (saline) instead of fecal suspension. Data values were indicated as mean ± SD (n = 6). Means with the same letters are not significantly different (p < 0.05). A, B, C, I Kruskal-Wallis test with Dunn’s post hoc test for non-parametric analysis. H, J, K One-way ANOVA with post hoc Bonferroni’s multiple comparisons test

Back to article page