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Fig. 5 | Microbiome

Fig. 5

From: Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Fig. 5

Normal IL-10 response to other commensal bacterial species or OMVs in inactive UC. Whole PBMC from healthy individuals (n = 4) or individuals with inactive UC (n = 3) were cultured for 20 h in the presence of 19 species of killed commensal bacteria. a Pooled data showing proportions of mDC expressing IL-10 are shown as mean (+/− SEM). PBMC from healthy individuals (HC, n = 4-5) or inactive UC patients (n = 3) were cultured for 20 h in the presence of Pn and Pn OMVs at varying concentrations. b The proportion of mDC expressing IL-6 or IL-10 from HC is shown. c Proportions of mDC expressing IL-6 (top) and IL-10 (bottom) from inactive UC and compared to HC are shown. Statistical significance was determined by ordinary one-way ANOVA with Dunnett’s multiple comparisons test or two-way ANOVA with Holm Sidak’s multiple comparisons test; ****p < 0.0001

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