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Table 2 Multidrug-resistant Gram-positive pathogens tested for sensitivity toward S. hominis S34-1 activity

From: Skin microbiota analysis-inspired development of novel anti-infectives

Type of species Comment Reference Antibiogramsa
CA-MRSAa
(ST1)
Strain MW2
(USA400)
[17] OXA, CFZ, PEN, CXM, FOX
HA-MRSA
(ST5)
Strain HS72, pathogenic, isolated from abscess [16] OXA, LVX, CLI, CFZ, FOS, ERY, AMK, PEN, GEN, FOX
CA-MRSA (ST8) SF8300
(USA300)
[18] OXA, CFZ, ERY, PEN, CXM, FOX
LA-MRSA
(ST9)
Pathogenic, isolated from bovine mastitis [19] OXA, LVX, CLI, CFZ, ERY, TGC, PEN, CXM, FOX
CA-MRSA
(ST30)
Strain SF-1497
(USA1100)
[18] OXA, CFZ, PEN, CXM, FOX
HA-MRSA
(ST36)
Strain SF 1208
(USA200)
[18] OXA, LVX, CLI, CFZ, ERY, SAM, PEN, CXM, FOX
CA-MRSA (ST59) Strain RJ-2, pathogenic, isolated from skin infection [15] OXA, CLI, ERY, PEN, CXM, FOX
CA-MRSA
(ST72)
Strain CN1, South Korea [20] OXA, CFZ, ERY, PEN, CXM, FOX
CA-MRSA
(ST80)
Strain 07-02662, Germany [21] OXA, ERY, PEN, FOX
HA-MRSA
(ST239)
Strain HS770, isolated from sputum [16] OXA, LVX, CLI, CFZ, ERY, AMK, SAM
CA-MRSA
(ST398)
Pathogenic, isolated from blood [22] OXA, ERY, PEN, FOX
Staphylococcus capitis Pathogenic, isolated from pleural fluid This study OXA, PEN, CIP, SXT, MXF, LVX
Staphylococcus epidermidis Pathogenic, isolated from blood This study OXA, PEN, CIP, ERY, MXF, LVX
Staphylococcus hominis Pathogenic, isolated from blood This study OXA, PEN, ERY
Streptococcus dysgalactiae Pathogenic, isolated from sputum This study ERY
Streptococcus agalactiae Pathogenic, isolated from urine This study CLI, LVX, CIP, MXF
Streptococcus salivarius Pathogenic, isolated from blood This study PEN
Streptococcus constellatus Pathogenic, isolated from blood This study PEN
Streptococcus pneumoniae Pathogenic, isolated from sputum This study PEN, CLI, OXA, LVX, ERY, CLR
VRE (Enterococcus faecium) Pathogenic, isolated from catheter This study VAN, PEN, CIP, LVX, ERY, LVX, TEC, TET, AMP, MXF, GEN, CLI, FOF
VRE (Enterococcus faecium) Pathogenic, isolated from urine This study VAN, PEN, AMP, CIP, LVX, MXF, ERY, CLI
VRE (Enterococcus faecium) Pathogenic, isolated from urine This study VAN, PEN, CIP, LVX, ERY, LVX, TEC, AMP, MXF, STR, CLI, FOF
  1. aAntibiograms were determined by disc diffusion on Mueller-Hinton agar according to Clinical and Laboratory Standards Institute guidelines
  2. Abbreviations: OXA oxacillin, PEN penicillin, LVX levofloxacin, CFZ cephazolin, CXM cefuroxime, FOX cefoxitin, CLI cephalexin, FOS fosfomycin, ERY erythromycin, AMK amikacin, GEN gentamicin, TGC tigecycline, SAM sulbactam/ampicillin, SXT sulphamethoxazole/trimethoprim, MXF moxifloxacin, CIP ciprofloxacin, TET tetracycline, CLR clarithromycin, VAN vancomycin, TEC teicoplanin, STR streptomycin, FOF nitrofurantoin, LA live-associated, CA community-associated, HA hospital-associated