Table 1 Krill oil (KO) supplementation increased the metabolites involved in pro-resolving pathways, particularly the biosynthesis of E-series resolvins. Fold change was calculated based on normalized peak intensities in Citrobacter rodentium induced colitis mice (CM) divided by those in healthy control mice (Down dysregulation) or those in KO divided by CM (Up dysregulation). Pathway: A: aspirin triggered resolvin E biosynthesis; B, aspirin-triggered lipoxin biosynthesis; C, lipoxin biosynthesis; and D, leukotriene biosynthesis
Metabolite | Pathway* | Fold change | P value | Dysregulation | m/z | RT |
|---|---|---|---|---|---|---|
(5S)-HPETE | D* | 0.33 | 0.0004 | Down | 381.2270 | 3.974 |
(15R)-hydroxyeicosapentaenoate | B*, C** | 0.36 | 0.0022 | Down | 365.2321 | 4.474 |
(5S)-HPETE | D* | 0.40 | 0.0024 | Down | 395.2428 | 5.266 |
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate | A** | 0.20 | 0.0037 | Down | 347.2217 | 7.754 |
15 [epi-] lipoxin A4/B4 | B*, C** | 0.37 | 0.0031 | Down | 411.2375 | 4.481 |
18R-hydroxy-eicosapentaenoate | A**, C**, D* | 0.34 | 0.0020 | Down | 363.2167 | 4.736 |
5S hydro(peroxy),18R-hydroxy-eicosapentaenoate | A** | 0.25 | 0.0009 | Down | 349.2010 | 5.702 |
Resolvin E1 | A** | 0.29 | 0.0023 | Down | 409.2217 | 3.840 |
15S-hydroxypentaenoate | B**, C*** | 1.70 | 0.0406 | Up | 340.2020 | 9.158 |
leukotriene A4 | A*, B**, C*** | 1.68 | 0.0067 | Up | 363.2167 | 5.253 |
Resolvin E2 | A*, B**, C*** | 1.79 | 0.0315 | Up | 315.1957 | 7.663 |