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Fig. 8 | Microbiome

Fig. 8

From: Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

Fig. 8

Krill oil supplementation mitigated Citrobacter rodentium induced colitis in mice. Krill oil (KO) improved bodyweight loss (a) and the spleen index (b), reduced the load of C. rodentium in the colon mucosa (c) and ameliorated histological scores (d). The expression of pro-inflammatory cytokines and chemokines, including IL1β, TNF, IL12B, IL17A, IL22, and CCL2 was significantly reduced by KO supplementation (e). f KO supplementation significantly improved the microbial dysbiosis index (MDI). *** Wilcoxon rank sum p < 0.001. g The 20 important genera selected by the random forests model for classification of the supplementation status (KO or PBS). h The relative abundance of three bacterial species, Lactobacillus reuteri, L. vaginalis, and Clostridium perfringens was reduced to the baseline level by KO supplementation. ***p < 0.001; **p < 0.01; *p < 0.05

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Microbiome

ISSN: 2049-2618

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