Fig. 1
From: Predictable modulation of cancer treatment outcomes by the gut microbiota
Taxonomic analysis of intestinal microbiota of cancer patients. a Sample collection scheme and dendrogram based on Bray-Curtis dissimilarity. b Alpha diversity (Shannon index) of the gut microbiota in responders (R) and non-responders (NR). c Non-metric multidimensional scaling (NMDS) plot of R and NR in human cancer samples based on the gut microbial compositions using Bray-Curtis dissimilarities (ANOSIM p = 0.0001). Intrapatient samples are linked to each other. d NMDS plot of R, NR, and HMP samples based on the gut microbial compositions at the species level using Bray-Curtis dissimilarities (ANOSIM p = 0.0001). e Phylogenetic composition of cancer samples at the phylum level. fFirmicutes/Bacteroidetes (F/B) ratio of cancer samples. g Heatmap of differentially abundant species detected in the comparison of R and NR (FDR p < 0.05, Wilcoxon rank-sum test). R-associated and NR-associated bacteria validated in mouse model are shown in red and cyan asterisks, respectively