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Table 3 Redundancy analyses for determination of percent variation in the lung microbiota, core taxa and satellite taxa explained by significant clinical and geographical distance variables between centres

From: Lung function and microbiota diversity in cystic fibrosis

 

Microbiota

Core taxa

Satellite taxa

Var. Exp (%)

pseudo-F

P (adj)

Var. Exp (%)

pseudo-F

P (adj)

Var. Exp (%)

pseudo-F

P (adj)

Age

2.2

3.6

0.046

2.4

4

0.021

1.4

2.1

0.008

Antibiotics

 Aztreonam

      

1.4

2.1

0.013

 Ceftazidime

      

1.4

2

0.008

 Colistin

2.2

3.6

0.036

2.2

3.2

0.042

1.2

1.8

0.008

 Flucloxacillin

2.4

3.7

0.042

5.4

8.2

0.016

1.2

1.8

0.007

 Meropenem

4.4

6.6

0.028

2.4

3.6

0.033

2.4

3.5

0.021

 Tobramycin

1.8

2.9

0.040

2.2

3.2

0.032

1.2

1.9

0.007

Clinical status

      

1

1.4

0.022

%FEV1

10.2

16.3

0.037

10.4

17.1

0.027

2.5

3

0.014

CFTR genotype

      

1

1.6

0.007

Sex

      

1.2

1.9

0.025

Region

1.8

3

0.049

2

3.3

0.041

1.4

2.1

0.009

Distance

 PCNM1

      

1.4

2.1

0.006

 PCNM3

      

1

1.4

0.036

 PCNM5

      

1.4

2.1

0.006

Clinical

25.0

  

27.0

  

17.3

  

Distance

      

3.8

  

Total

25.0

  

27.0

  

21.1

  
  1. Principle coordinates neighbour matrices (PCNM) were used as potential explanatory values of distance between CF centres. Var. Exp (%) the percentage of microbiota variation explained by a parameter given the redundancy analysis. P(adj) adjusted significance value following false discovery rate correction. Clinical status is stable or in treatment for acute pulmonary exacerbation