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Table 3 Redundancy analyses for determination of percent variation in the lung microbiota, core taxa and satellite taxa explained by significant clinical and geographical distance variables between centres

From: Lung function and microbiota diversity in cystic fibrosis

 MicrobiotaCore taxaSatellite taxa
Var. Exp (%)pseudo-FP (adj)Var. Exp (%)pseudo-FP (adj)Var. Exp (%)pseudo-FP (adj)
Age2.23.60.0462.440.0211.42.10.008
Antibiotics
 Aztreonam      1.42.10.013
 Ceftazidime      1.420.008
 Colistin2.23.60.0362.23.20.0421.21.80.008
 Flucloxacillin2.43.70.0425.48.20.0161.21.80.007
 Meropenem4.46.60.0282.43.60.0332.43.50.021
 Tobramycin1.82.90.0402.23.20.0321.21.90.007
Clinical status      11.40.022
%FEV110.216.30.03710.417.10.0272.530.014
CFTR genotype      11.60.007
Sex      1.21.90.025
Region1.830.04923.30.0411.42.10.009
Distance
 PCNM1      1.42.10.006
 PCNM3      11.40.036
 PCNM5      1.42.10.006
Clinical25.0  27.0  17.3  
Distance      3.8  
Total25.0  27.0  21.1  
  1. Principle coordinates neighbour matrices (PCNM) were used as potential explanatory values of distance between CF centres. Var. Exp (%) the percentage of microbiota variation explained by a parameter given the redundancy analysis. P(adj) adjusted significance value following false discovery rate correction. Clinical status is stable or in treatment for acute pulmonary exacerbation