Fig. 4
a Methanogenic pathway reconstructions in five archaeal MAGs. CoA, coenzymeA; MFR, methanofuran; H4MPT, tetrahydrosarcinapterin; HS-CoM, coenzyme M; HS-CoB, coenzyme B; MP, methanophenazine; Feox, Ferredoxin; F420, coenzyme 420; ack, acetate kinase; pta, phosphate acetyltransferase; cdh, acetyl-CoA decarbonylase; coo, carbon-monoxide dehydrogenase; mta, methano-specific coenzyme M methyltransferase; mtb, methylamine-specific coenzyme M methyltransferase; fwd, formylmethanofuran dehydrogenase; ftr, formylmethanofuran--tetrahydromethanopterin N-formyltransferase; mch, methenyltetrahydromethanopterin cyclohydrolase; mtd, methylene tetrahydromethanopterin reductase; mer, F420-dependent methylenetetrahydromethanopterin dehydrogenase; hdr A-C, heterodisulfide reductase subunits A-C; hdr DE, heterodisulfide reductase D and E; vho, methanophenazine-reducing hydrogenase; fpo, F420H2 dehydrogenase; frh, coenzyme F420 hydrogenase subunit; mvh, F420-non-reducing hydrogenase; fdh, formate dehydrogenase; ech, Escherichia coli hydrogenase 3; eha, energy-converting hydrogenase A; ehb, energy-converting hydrogenase B. b The expression of genes related to methanogenesis. The colors represent different steps of methanogenic pathways. Significant up (red) and down (green) regulation of genes (evaluated with edgeR) is indicated by colored numbers