TY - JOUR AU - Chijiiwa, Rieka AU - Hosokawa, Masahito AU - Kogawa, Masato AU - Nishikawa, Yohei AU - Ide, Keigo AU - Sakanashi, Chikako AU - Takahashi, Kai AU - Takeyama, Haruko PY - 2020 DA - 2020/01/23 TI - Single-cell genomics of uncultured bacteria reveals dietary fiber responders in the mouse gut microbiota JO - Microbiome SP - 5 VL - 8 IS - 1 AB - The gut microbiota can have dramatic effects on host metabolism; however, current genomic strategies for uncultured bacteria have several limitations that hinder their ability to identify responders to metabolic changes in the microbiota. In this study, we describe a novel single-cell genomic sequencing technique that can identify metabolic responders at the species level without the need for reference genomes, and apply this method to identify bacterial responders to an inulin-based diet in the mouse gut microbiota. SN - 2049-2618 UR - https://doi.org/10.1186/s40168-019-0779-2 DO - 10.1186/s40168-019-0779-2 ID - Chijiiwa2020 ER -